Tyr138
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Home > Phosphorylation Site Page: > Tyr138  -  PTEN (human)

Site Information
TGVMICAyLLHRGKF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4000968

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on PTEN:
phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, inhibited ( 1 )

References 

1

Chatterjee N, et al. (2019) Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep 28, 2317-2330.e8
31461649   Curated Info

2

Maddika S, et al. (2011) WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 13, 728-33
21532586   Curated Info