Ser80
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Home > Phosphorylation Site Page: > Ser80  -  K8 (mouse)

Site Information
TVNQSLLsPLkLEVD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448539

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 4 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 , 5 ) , phospho-antibody ( 4 , 5 , 6 , 7 , 8 ) , western blotting ( 4 , 8 )
Relevant cell line - cell type - tissue:
germ cell ( 1 ) , hepatocyte-liver ( 6 , 8 ) , keratinocyte-skin ( 1 ) , liver ( 2 , 3 , 4 , 5 , 7 ) , liver [leptin (mouse), homozygous knockout] ( 3 )

Upstream Regulation
Putative in vivo kinases:
P38A (mouse) ( 6 )
Treatments:
DDC ( 8 ) , Fas ( 5 ) , griseofulvin ( 4 , 7 ) , SB202190 ( 6 )

Downstream Regulation
Effects of modification on K8:
intracellular localization ( 8 ) , molecular association, regulation ( 6 )
Effects of modification on biological processes:
apoptosis, inhibited ( 5 ) , carcinogenesis, induced ( 1 ) , cytoskeletal reorganization ( 8 )

References 

1

Tiwari R, et al. (2021) Generation of a tissue-specific transgenic model for K8 phosphomutants: A tool to investigate the role of K8 phosphorylation during skin carcinogenesis in vivo. Cell Biol Int
33847415   Curated Info

2

Robles MS, Humphrey SJ, Mann M (2017) Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab 25, 118-127
27818261   Curated Info

3

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

4

Fortier AM, Riopel K, Désaulniers M, Cadrin M (2010) Novel insights into changes in biochemical properties of keratins 8 and 18 in griseofulvin-induced toxic liver injury. Exp Mol Pathol 89, 117-25
20643122   Curated Info

5

Ku NO, Omary MB (2006) A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol 174, 115-25
16818723   Curated Info

6

Nan L, et al. (2006) Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor. Exp Mol Pathol 80, 228-40
16563375   Curated Info

7

Fausther M, Villeneuve L, Cadrin M (2004) Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice. Comp Hepatol 3, 5
15307891   Curated Info

8

Stumptner C, et al. (2000) Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am J Pathol 156, 77-90
10623656   Curated Info

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