Lys254

Site Information
EVkVEGPkEELEVAG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3982501

In vivo Characterization
Methods used to characterize site in vivo:	electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	adrenal cancer ( 2 ) , pheochromocytoma ( 2 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:	Balb/c(10)1 (fibroblast) ( 2 ) , HeLa (cervical) ( 2 ) , PC-12 (chromaffin) ( 2 ) , SH-SY5Y (neural crest) ( 1 )

Downstream Regulation
Effects of modification on ELK1:	intracellular localization ( 1 , 2 ) , sumoylation ( 1 )
Effects of modification on biological processes:	cell differentiation, inhibited ( 2 ) , transcription, induced ( 1 )

References
1	Kelle D, Kırımtay K, Selçuk E, Karabay A (2019) Elk1 affects katanin and spastin proteins via differential transcriptional and post-transcriptional regulations. PLoS One 14, e0212518 30789974 Curated Info
2	Salinas S, et al. (2004) SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. J Cell Biol 165, 767-73 15210726 Curated Info