Thr183
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Site Information
HDHtGFLtEyVAtRW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447593

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 201 ) , electrophoretic mobility shift ( 134 ) , flow cytometry ( 176 ) , immunoassay ( 32 ) , immunoprecipitation ( 6 , 8 , 16 , 58 , 82 , 102 , 175 ) , mass spectrometry ( 5 , 9 , 19 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 98 , 99 , 100 , 101 , 104 , 105 , 117 , 118 , 137 ) , mutation of modification site ( 6 , 95 , 103 , 122 , 131 , 169 , 174 , 201 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 78 , 79 , 80 , 82 , 95 , 96 , 97 , 102 , 103 , 106 , 107 , 108 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 193 , 194 , 195 , 196 , 197 , 198 , 200 , 202 , 203 , 204 , 205 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 8 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 65 , 78 , 79 , 80 , 82 , 95 , 96 , 97 , 102 , 103 , 106 , 107 , 108 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 138 , 140 , 141 , 142 , 143 , 144 , 149 , 151 , 153 , 154 , 155 , 156 , 157 , 160 , 161 , 163 , 164 , 167 , 168 , 169 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 186 , 187 , 188 , 189 , 191 , 193 , 196 , 197 , 198 , 203 , 204 , 205 )
Disease tissue studied:
Alzheimer's disease ( 148 ) , adrenal cancer ( 83 , 84 , 85 , 86 , 87 , 97 , 98 , 99 , 100 , 101 , 122 , 135 , 180 , 182 , 186 , 203 ) , pheochromocytoma ( 83 , 84 , 85 , 86 , 87 , 97 , 98 , 99 , 100 , 101 , 122 , 135 , 180 , 182 , 186 , 203 ) , bone cancer ( 183 ) , brain cancer ( 95 ) , glioma ( 95 ) , colorectal cancer ( 114 ) , colorectal carcinoma ( 114 ) , liver cancer ( 141 , 172 , 197 ) , pancreatic cancer ( 175 , 187 ) , pancreatic carcinoma ( 175 , 187 ) , diabetes mellitus ( 16 )
Relevant cell line - cell type - tissue:
'brain, amygdala' ( 13 , 64 ) , 'brain, brainstem' ( 19 ) , 'brain, caudate-putamen' ( 64 ) , 'brain, cerebellum' ( 19 ) , 'brain, cerebral cortex' ( 19 , 32 , 56 , 64 , 125 , 194 ) , 'brain, forebrain' ( 194 ) , 'brain, hippocampus' ( 1 , 7 , 13 , 41 , 64 , 129 , 149 , 157 , 194 , 195 ) , 'brain, hippocampus, dentate gyrus' ( 80 , 169 ) , 'brain, hypothalamus' ( 13 ) , 'brain, nucleus accumbens' ( 64 ) , 'brain, striatum' ( 1 , 56 , 129 , 153 ) , 'brain, ventral tegmental area' ( 64 ) , 'granulosa, luteal' ( 188 ) , 'kidney, inner medulla' ( 137 ) , 'muscle, skeletal' ( 36 , 163 , 179 , 181 ) , 'muscle, smooth' ( 31 , 196 ) , 'muscle, smooth'-'heart, artery' ( 35 , 107 ) , 'muscle, smooth'-thoracic aorta ( 171 ) , 'neuron, cerebellar granule'-brain ( 60 , 148 ) , 'neuron, cortical' ( 6 , 25 , 177 ) , 'neuron, cortical'-brain ( 1 , 40 , 116 , 156 ) , 'neuron, hippocampal'-'brain, embryonic' ( 25 ) , 'neuron, hippocampal'-brain ( 40 , 173 , 185 ) , 293 (epithelial) ( 5 , 58 , 79 , 136 , 150 , 201 ) , 3T3 (fibroblast) ( 5 , 131 ) , 3T3-L1 (fibroblast) ( 59 , 141 ) , A7r5 ('muscle, smooth') ( 198 ) , adipocyte ( 113 , 128 ) , adipocyte-adipose tissue ( 9 , 151 ) , adipose tissue ( 19 , 164 ) , beta-pancreas ( 26 , 30 ) , brain ( 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 117 , 118 ) , C2C12 (myoblast) ( 106 ) , C6 (glial) ( 95 ) , COS (fibroblast) ( 14 , 167 , 178 ) , epithelial-'kidney, tubule' ( 11 ) , fibroblast-heart ( 3 , 96 , 134 ) , GEC (epithelial) ( 147 ) , GG-CL (ovarian) ( 28 ) , GH4C1 (pituitary cell) ( 102 ) , GN4 (epithelial) ( 165 ) , granulosa ( 145 ) , H-35 (hepatic) ( 197 ) , H4IIe (hepatic) ( 172 ) , H9c2 (myoblast) ( 59 , 120 ) , heart ( 10 , 78 , 79 ) , HeLa (cervical) ( 6 , 27 ) , hepatocyte ( 143 ) , HepG2 (hepatic) ( 141 ) , HIRcB (fibroblast) ( 59 , 61 ) , HIT (pancreatic) ( 158 ) , IEC-18 (epithelial) ( 114 ) , IEC-6 (epithelial) ( 132 , 191 ) , INS-1 (pancreatic) ( 175 , 187 ) , L6 (myoblast) ( 57 , 65 , 141 ) , liver ( 19 , 127 , 140 , 160 ) , lung ( 19 , 22 ) , M059J (glial) ( 110 ) , MEF (fibroblast) ( 103 , 110 ) , muscle ( 19 ) , myocardium ( 133 ) , myocyte ( 198 ) , myocyte-heart ( 62 , 79 , 82 , 96 , 106 , 108 , 150 , 154 , 170 , 174 , 176 ) , myometrial ( 144 ) , neuron-'brain, cerebral cortex' ( 126 , 135 ) , neuron-'brain, hippocampus' ( 39 , 139 , 142 ) , neuron-'brain, hypothalamus' ( 184 ) , neuron-spinal cord ( 124 ) , neuron:synaptosome-'brain, cerebral cortex' ( 15 ) , NRK (fibroblast) ( 204 ) , pancreatic acini ( 115 ) , PC-12 (chromaffin) ( 83 , 84 , 85 , 86 , 87 , 97 , 98 , 99 , 100 , 101 , 104 , 105 , 122 , 135 , 152 , 159 , 180 , 182 , 186 , 202 , 203 , 205 ) , preovulatory follicle granulosa ( 4 ) , R22 ('muscle, smooth') ( 103 ) , Rat1 (fibroblast) ( 59 , 110 ) , Rat2 (fibroblast) [TrkB (rat)] ( 138 ) , RBL-2H3 (basophil) ( 63 , 193 , 200 ) , RBL-2H3 (basophil) [transfection] ( 38 ) , REF52 (fibroblast) ( 112 , 167 ) , RIE (epithelial) ( 111 , 130 ) , RIE (epithelial) [PPAR-gamma (mouse)] ( 130 ) , RIN (epithelial) ( 158 , 161 ) , RM-4 (mesothelial) ( 166 ) , spinal cord ( 24 ) , stem ( 2 ) , stomach ( 19 ) , SYF (fibroblast) ( 103 ) , T84 (intestinal) ( 114 ) , UMR106 (bone cell) ( 183 ) , vascular ( 16 ) , vascular smooth muscle cell ('muscle, smooth') ( 103 , 121 , 123 , 136 , 189 , 190 ) , VSMC ( 16 , 29 ) , VSMC ('muscle, smooth') ( 37 ) , VSMC-aorta ( 146 ) , WB-F344 (epithelial) ( 155 )

Upstream Regulation
Regulatory protein:
CALB1 (rat) ( 142 ) , caveolin-2 (rat) ( 8 , 61 ) , DISC1 (human) ( 126 ) , DUSP6 (human) ( 150 ) , DYN1 (rat) ( 29 ) , EEA1 (rat) ( 29 ) , FAK (rat) ( 31 , 82 ) , FAK iso2 (mouse) ( 196 ) , HER2 (rat) ( 16 ) , HRas (human) ( 147 , 165 ) , IRS1 (rat) ( 8 ) , ITGA5 (human) ( 111 ) , KRas (rat) ( 191 ) , LEPR (mouse) ( 158 ) , LYN (rat) ( 38 ) , MEK1 (rat) ( 174 ) , NDST1 (human) ( 31 ) , PAK1 (rat) ( 130 ) , PKCD (human) ( 95 ) , PKCD (rat) ( 95 ) , PKCE (rat) ( 97 ) , PPAR-gamma (mouse) ( 130 ) , PPP1R14A (rat) ( 131 ) , prolactin (human) ( 13 ) , PTP-SL (human) ( 182 ) , PXN (rat) ( 26 ) , Pyk2 (rat) ( 39 ) , RAP2A (human) ( 149 ) , RHOA (human) ( 147 ) , SH2-B-beta (rat) ( 192 ) , SHP-2 (rat) ( 82 , 138 ) , SIRT7 (human) ( 3 )
Putative in vivo kinases:
MEK1 (rat) ( 112 )
Kinases, in vitro:
ERK2 (rat) ( 5 ) , MEK1 (human) ( 79 , 201 ) , MEK1 (rabbit) ( 206 ) , MEK1 (rat) ( 112 )
Putative upstream phosphatases:
DUSP27 (rat) ( 28 ) , PPP2CB (rat) ( 119 ) , STEP (rat) ( 6 )
Phosphatases, in vitro:
DUSP27 (rat) ( 28 )
Treatments:
1400W ( 57 , 146 ) , 17-beta-estradiol ( 25 ) , 2,2'-DCB ( 144 ) , 4-AP ( 15 , 156 ) , 4-methycatechol ( 177 ) , acadesine ( 145 ) , adrenalectomy ( 133 ) , adriamycin ( 155 ) , AEBSF ( 57 , 146 ) , AG1478 ( 4 , 96 , 103 , 132 , 134 , 155 , 191 ) , AG490 ( 28 , 170 ) , AG825 ( 16 ) , angiopoietin-1 ( 154 ) , angiopoietin-2 ( 154 ) , angiotensin ( 136 ) , angiotensin_2 ( 29 , 35 , 37 , 57 , 79 , 114 , 134 , 146 ) , anisodine ( 2 ) , anisomycin ( 205 ) , anoxia ( 148 ) , anthrax_toxin ( 204 ) , anti-CD29 ( 166 ) , anti-FcR1 ( 38 ) , antigenic stimulation ( 63 ) , APV ( 169 , 199 ) , asbestos ( 166 ) , aspirin ( 63 ) , azaserine ( 161 ) , BAPTA-AM ( 37 , 188 ) , BDNF ( 40 , 56 , 135 , 138 , 177 ) , berberine ( 15 , 36 ) , bicuculline ( 156 , 173 ) , bisindolylmaleimide ( 97 ) , BIX02188 ( 24 ) , BMP2 ( 202 ) , bradykinin ( 128 ) , C5b-9 ( 147 ) , caffeine ( 125 ) , cAMP_analog ( 159 ) , carbachol ( 79 ) , cell_adhesion ( 143 ) , CGS_21680 ( 180 ) , cholecystokinin ( 115 ) , ciglitazone ( 165 ) , Clostridium_lethal_toxin ( 193 ) , Clostridium_toxin_B ( 193 ) , cobalt ( 97 ) , colforsin ( 159 , 184 , 199 ) , complement_8 ( 147 ) , compound_401 ( 110 ) , compound_56 ( 155 ) , CPCCOEt ( 129 ) , CPT ( 125 ) , culturing_of_cells ( 116 , 140 ) , CV11974 ( 146 ) , cyclic_stretch ( 82 , 108 ) , cycloheximide ( 177 ) , depolarization ( 40 , 157 , 184 ) , DHPG ( 129 , 153 ) , diabetes ( 10 , 16 ) , DNP ( 200 ) , DPI ( 146 ) , ebselen ( 146 ) , eflornithine ( 132 ) , EGF ( 58 , 81 , 96 , 112 , 114 , 122 , 132 , 134 , 143 , 147 , 159 , 167 , 178 , 182 , 183 , 187 , 201 ) , electrical_stimulation ( 125 , 169 ) , endothelin ( 176 ) , estradiol ( 113 ) , ethyl_pyruvate ( 22 ) , etoposide ( 95 ) , exenatide ( 30 ) , exercise ( 195 ) , Fas ( 16 ) , fibronectin ( 112 , 167 ) , GABA ( 184 ) , gefitinib ( 165 ) , genistein ( 170 , 198 ) , GF109203X ( 96 , 114 , 157 ) , glucosamine ( 161 ) , glucose ( 26 , 161 , 187 ) , glucose_starvation ( 109 ) , glycine ( 173 ) , Go_6976 ( 37 , 96 ) , gomisin_A ( 27 ) , gomisin_N ( 27 ) , GRGDSP ( 166 ) , H-7 ( 135 ) , H-89 ( 113 , 143 , 159 ) , H2O2 ( 96 , 134 ) , heart failure ( 78 ) , hemorrhage ( 160 ) , heparin sodium ( 31 ) , herbimycin_A ( 198 ) , heroin_withdrawal ( 64 ) , HGF ( 174 ) , high_glucose ( 16 ) , hindlimb unloading ( 32 ) , hyperglycemia ( 194 ) , hypoxia ( 2 , 203 ) , IBMX ( 159 ) , IGF-1 ( 145 , 187 ) , IL-1b ( 121 ) , IL-6 ( 170 , 197 ) , insulin ( 8 , 59 , 61 , 65 , 109 , 120 , 128 , 133 , 141 , 150 , 151 , 172 , 189 , 197 ) , interstitial flow ( 31 ) , ischemia/reperfusion ( 80 , 140 , 194 ) , isoproterenol ( 134 ) , JNK_inhibitor_I ( 161 ) , K252a ( 135 , 177 ) , kainic_acid ( 139 ) , KCl ( 198 , 199 ) , ketamine ( 1 ) , KN-93 ( 7 ) , L-NAME ( 146 ) , lactoferrin ( 9 ) , laminin-1 ( 154 ) , leptin ( 34 , 158 ) , LIF ( 197 ) , long-term_potentiation ( 7 , 169 ) , LPA ( 114 ) , LPS ( 22 ) , LY294002 ( 40 , 56 , 110 , 130 , 140 , 176 , 190 , 191 ) , lysophosphatidylcholine ( 189 ) , metformin ( 141 ) , metoprolol ( 133 ) , MG132 ( 173 ) , MPEP ( 129 ) , MPP+ ( 60 ) , MSX-3 ( 125 ) , muscimol ( 184 ) , muscle atrophy ( 181 ) , myricetin ( 57 , 146 ) , NAC ( 97 , 165 ) , nafenopin ( 165 ) , naltrexone ( 64 ) , neuregulin ( 78 , 79 ) , neurotrophin-3 ( 14 ) , NGF ( 122 , 135 , 152 , 159 , 180 , 186 , 192 , 202 , 203 , 205 ) , nimodipine ( 199 ) , NMDA ( 39 , 199 ) , norepinephrine ( 96 ) , NS_1231 ( 186 ) , NSC_295642 ( 4 ) , NSC_663284 ( 4 , 28 ) , NSC_95397 ( 28 ) , okadaic_acid ( 4 , 14 , 28 , 153 ) , oncostatin_M ( 197 ) , ouabain ( 198 ) , OXO ( 111 ) , PAF ( 41 ) , Pasteurella_multocida_toxin ( 96 , 134 ) , PCP ( 56 ) , PD123319 ( 146 ) , PD153035 ( 165 ) , PD169316 ( 163 ) , PD184352 ( 37 , 162 ) , PD98059 ( 4 , 14 , 15 , 16 , 26 , 32 , 56 , 60 , 109 , 115 , 121 , 140 , 157 , 163 , 170 , 174 , 176 , 177 , 180 , 183 , 189 , 191 , 196 , 204 , 205 ) , PDGF ( 37 , 107 , 110 , 190 , 196 ) , peptide_agonist ( 168 ) , PF-573228 ( 31 ) , PGE2a ( 188 ) , phenylephrine ( 79 , 150 ) , phorbol_ester ( 96 , 114 , 134 , 147 , 200 ) , pleiotrophin ( 106 ) , PP1 ( 62 , 134 ) , PP2 ( 30 , 82 , 143 , 153 , 157 , 159 , 165 , 167 ) , PP3 ( 157 , 165 ) , PRL ( 28 ) , PTH ( 183 ) , PTP1B_inhibitor ( 28 ) , PTX ( 134 ) , PTZ ( 139 ) , putrescine ( 132 ) , rapamycin ( 40 , 65 , 109 , 110 , 141 , 151 ) , resveratrol ( 171 ) , RGDS ( 166 ) , Ro31-8220 ( 114 ) , RS5444 ( 130 ) , SB202190 ( 140 ) , SB203580 ( 140 , 162 , 176 , 205 ) , seliciclib ( 135 ) , serum ( 11 , 147 , 171 ) , SHP2_inhibitor ( 28 ) , siRNA ( 28 , 95 , 97 , 131 , 136 ) , sorbitol ( 162 ) , SP600125 ( 163 , 176 ) , spermidine ( 132 ) , spermine ( 132 ) , SR7037 ( 26 ) , SSA412 ( 62 ) , SU6656 ( 80 , 107 ) , tautomycin ( 4 ) , TeTx ( 60 ) , TGF-alpha ( 187 ) , TGF-beta ( 103 , 185 ) , thrombin ( 96 , 134 , 190 ) , TNF ( 27 , 163 ) , TNP-OVA ( 193 ) , TRAIL ( 95 ) , trauma ( 160 ) , TRH ( 102 ) , troglitazone ( 165 ) , TTX ( 173 ) , U0126 ( 11 , 14 , 34 , 37 , 40 , 59 , 80 , 96 , 102 , 103 , 113 , 114 , 115 , 120 , 121 , 122 , 130 , 134 , 135 , 136 , 145 , 146 , 151 , 153 , 155 , 156 , 157 , 165 , 172 , 176 , 185 , 197 ) , urofollitropin ( 4 , 145 ) , UV ( 162 , 203 ) , vanadate ( 140 ) , VEGF ( 140 ) , vitronectin ( 154 ) , W-7 ( 188 ) , wortmannin ( 59 , 60 , 109 , 113 , 135 , 151 , 193 ) , Y15 ( 26 ) , Y27632 ( 103 , 147 ) , Zn(2+) ( 6 , 97 )

Downstream Regulation
Effects of modification on ERK2:
activity, induced ( 166 , 170 , 184 , 195 ) , enzymatic activity, induced ( 139 , 150 , 167 , 202 , 206 ) , intracellular localization ( 26 , 61 , 167 , 184 ) , molecular association, regulation ( 201 )
Effects of modification on biological processes:
cell adhesion, altered ( 167 ) , cell growth, altered ( 80 ) , cytoskeletal reorganization ( 167 ) , translation, altered ( 150 )
Induce interaction with:
MEK1 (human) ( 201 )

Disease / Diagnostics Relevance
Relevant diseases:
major depressive disorder ( 126 ) , uteroplacental insufficiency ( 127 )

References 

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Poddar R, Rajagopal S, Shuttleworth CW, Paul S (2016) Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION. J Biol Chem 291, 813-25
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Melgarejo da Rosa M, et al. (2016) Synaptic GluN2B/CaMKII-α Signaling Induces Synapto-Nuclear Transport of ERK and Jacob. Front Mol Neurosci 9, 66
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8

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13

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14

Funahashi Y, et al. (2013) ERK2-Mediated Phosphorylation of Par3 Regulates Neuronal Polarization. J Neurosci 33, 13270-85
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15

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16

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17

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18

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20

Andreu-Pérez P, et al. (2011) Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Sci Signal 4, ra58
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21

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25

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26

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28

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29

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34

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40

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41

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42

Hu Y (2010) CST Curation Set: 8873; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

43

Hu Y (2010) CST Curation Set: 8874; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

44

Hu Y (2010) CST Curation Set: 8884; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

45

Hu Y (2010) CST Curation Set: 8921; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

46

Hu Y (2010) CST Curation Set: 8931; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

47

Hu Y (2010) CST Curation Set: 8930; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

48

Hu Y (2010) CST Curation Set: 8923; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

49

Hu Y (2010) CST Curation Set: 8885; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

50

Hu Y (2010) CST Curation Set: 8919; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

51

Hu Y (2010) CST Curation Set: 8918; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

52

Hu Y (2010) CST Curation Set: 8922; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

53

Hu Y (2010) CST Curation Set: 8875; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

54

Hu Y (2010) CST Curation Set: 8920; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

55

Hu Y (2010) CST Curation Set: 8880; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

56

Xia Y, et al. (2010) Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology 58, 330-6
19887077   Curated Info

57

Csibi A, Communi D, Müller N, Bottari SP (2010) Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms. PLoS One 5, e10070
20383279   Curated Info

58

Sacco F, et al. (2009) Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. J Biol Chem 284, 22048-58
19494114   Curated Info

59

Kwon H, Jeong K, Pak Y (2009) Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis. J Cell Mol Med 13, 1549-64
19778377   Curated Info

60

Chaïb-Oukadour I, et al. (2009) Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity. Mol Cell Neurosci 41, 297-303
19344769   Curated Info

61

Kwon H, et al. (2009) Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin. Biochim Biophys Acta 1793, 1325-33
19427337   Curated Info

62

Lee DI, et al. (2009) Activation of (Na+ + K+)-ATPase modulates cardiac L-type Ca2+ channel function. Mol Pharmacol 75, 774-81
19122004   Curated Info

63

Togo K, et al. (2009) Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx. Clin Immunol 131, 145-56
19144570   Curated Info

64

Edwards S, Graham DL, Whisler KN, Self DW (2009) Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. Synapse 63, 224-35
19084907   Curated Info

65

Feldman ME, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7, e38
19209957   Curated Info

66

Guo A (2009) CST Curation Set: 5871; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

67

Guo A (2009) CST Curation Set: 5870; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

68

Guo A (2009) CST Curation Set: 5867; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

69

Guo A (2009) CST Curation Set: 5868; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

70

Guo A (2009) CST Curation Set: 5869; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

71

Guo A (2009) CST Curation Set: 5862; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

72

Guo A (2009) CST Curation Set: 5863; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

73

Guo A (2009) CST Curation Set: 5864; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

74

Guo A (2009) CST Curation Set: 5865; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

75

Guo A (2009) CST Curation Set: 5866; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

76

Guo A (2009) CST Curation Set: 5861; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

77

Guo A (2009) CST Curation Set: 5860; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

78

Doggen K, et al. (2009) Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure. J Mol Cell Cardiol 46, 33-8
19010331   Curated Info

79

Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ (2009) A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med 15, 75-83
19060905   Curated Info

80

Tian HP, et al. (2009) Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus. BMC Neurosci 10, 139
19943942   Curated Info

81

Philippar U, et al. (2008) A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 15, 813-28
19081071   Curated Info

82

Marin TM, et al. (2008) Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways. Circ Res 103, 813-24
18757826   Curated Info

83

Stokes M (2008) CST Curation Set: 5264; Year: 2008; Biosample/Treatment: cell line, PC-12/untreated; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

84

Stokes M (2008) CST Curation Set: 5265; Year: 2008; Biosample/Treatment: cell line, PC-12/PACAP; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

85

Stokes M (2008) CST Curation Set: 5266; Year: 2008; Biosample/Treatment: cell line, PC-12/PACAP; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

86

Stokes M (2008) CST Curation Set: 5267; Year: 2008; Biosample/Treatment: cell line, PC-12/PACAP; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

87

Stokes M (2008) CST Curation Set: 5268; Year: 2008; Biosample/Treatment: cell line, PC-12/PACAP; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

88

Guo A (2008) CST Curation Set: 5216; Year: 2008; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

89

Guo A (2008) CST Curation Set: 5217; Year: 2008; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

90

Guo A (2008) CST Curation Set: 5218; Year: 2008; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

91

Guo A (2008) CST Curation Set: 5219; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

92

Guo A (2008) CST Curation Set: 5220; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

93

Guo A (2008) CST Curation Set: 5221; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

94

Guo A (2008) CST Curation Set: 5222; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

95

Lomonaco SL, et al. (2008) Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide. J Biol Chem 283, 17731-9
18434324   Curated Info

96

Ozgen N, et al. (2008) Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart. J Biol Chem 283, 17009-19
18378685   Curated Info

97

Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH (2008) A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem 283, 14430-44
18375950   Curated Info

98

Stokes M (2008) CST Curation Set: 4008; Year: 2008; Biosample/Treatment: cell line, PC-12/untreated; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

99

Stokes M (2008) CST Curation Set: 4009; Year: 2008; Biosample/Treatment: cell line, PC-12/EGF; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

100

Stokes M (2008) CST Curation Set: 4012; Year: 2008; Biosample/Treatment: cell line, PC-12/untreated; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

101

Stokes M (2008) CST Curation Set: 4013; Year: 2008; Biosample/Treatment: cell line, PC-12/PACAP; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

102

Fujita T, Ryser S, Piuz I, Schlegel W (2008) Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells. Mol Cell Biol 28, 1630-43
18086894   Curated Info

103

Samarakoon R, Higgins SP, Higgins CE, Higgins PJ (2008) TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling. J Mol Cell Cardiol 44, 527-38
18255094   Curated Info

104

Guo A (2008) CST Curation Set: 3877; Year: 2008; Biosample/Treatment: cell line, PC-12/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

105

Guo A (2008) CST Curation Set: 3878; Year: 2008; Biosample/Treatment: cell line, PC-12/NGF; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

106

Li J, et al. (2007) The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. J Biol Chem 282, 34984-93
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107

Xu K, Kitchen CM, Shu HK, Murphy TJ (2007) Platelet-derived Growth Factor-induced Stabilization of Cyclooxygenase 2 mRNA in Rat Smooth Muscle Cells Requires the c-Src Family of Protein-tyrosine Kinases. J Biol Chem 282, 32699-709
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108

Senyo SE, Koshman YE, Russell B (2007) Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes. FEBS Lett 581, 4241-7
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Giraud J, et al. (2007) Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol 21, 2294-302
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110

Ballou LM, et al. (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem 282, 24463-70
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Oh MA, et al. (2007) PKCdelta and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin alpha5 but not its tailless mutant. J Cell Sci 120, 2717-30
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112

Park ER, Eblen ST, Catling AD (2007) MEK1 activation by PAK: a novel mechanism. Cell Signal 19, 1488-96
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113

Jaubert AM, et al. (2007) Nongenomic estrogen effects on nitric oxide synthase activity in rat adipocytes. Endocrinology 148, 2444-52
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114

Jiang X, Sinnett-Smith J, Rozengurt E (2007) Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell Signal 19, 1000-10
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115

Berna MJ, et al. (2007) CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim Biophys Acta 1773, 483-501
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116

Liang MH, Chuang DM (2007) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J Biol Chem 282, 3904-17
17148450   Curated Info

117

Guo A (2007) CST Curation Set: 2238; Year: 2007; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

118

Guo A (2007) CST Curation Set: 2239; Year: 2007; Biosample/Treatment: tissue, brain/ischemia 20'; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

119

Saraf A, Virshup DM, Strack S (2007) Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. J Biol Chem 282, 573-80
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120

Nascimento EB, et al. (2006) Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 55, 3221-8
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121

Xu S, Bayat H, Hou X, Jiang B (2006) Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta. Am J Physiol Cell Physiol 291, C1336-45
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122

Pellegrino MJ, Stork PJ (2006) Sustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells. J Neurochem 99, 1480-93
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123

Nomiyama T, et al. (2006) The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J Biol Chem 281, 33467-76
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124

Deinhardt K, et al. (2006) Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 52, 293-305
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125

Quiroz C, et al. (2006) Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation. J Neurosci 26, 10808-12
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126

Hashimoto R, et al. (2006) Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 15, 3024-33
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127

Fu Q, et al. (2006) Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5. FASEB J 20, 2127-9
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128

Beard KM, Lu H, Ho K, Fantus IG (2006) Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase. Diabetes 55, 2678-87
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129

Page G, et al. (2006) Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes. Neurochem Int 49, 413-21
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130

Chen L, et al. (2006) Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2. J Biol Chem 281, 24575-87
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131

Jin H, Sperka T, Herrlich P, Morrison H (2006) Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 442, 576-9
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132

Bhattacharya S, Ray RM, Johnson LR (2006) Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J 397, 437-47
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133

Samuelsson AM, et al. (2006) Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Physiol Heart Circ Physiol 291, H787-96
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134

Obreztchikova M, et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J Biol Chem 281, 20197-204
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135

Ng YP, Cheung ZH, Ip NY (2006) STAT3 as a downstream mediator of Trk signaling and functions. J Biol Chem 281, 15636-44
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