Ser35
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Home > Phosphorylation Site Page: > Ser35  -  K18 (mouse)

Site Information
rPAssAAsVyAGAGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447733

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 5 ) , mass spectrometry ( 2 , 3 , 4 , 6 , 7 , 8 ) , phospho-antibody ( 5 , 9 , 11 ) , western blotting ( 5 )
Relevant cell line - cell type - tissue:
Hepa 1-6 (epithelial) ( 7 ) , hepatocyte-liver ( 11 ) , kidney ( 4 ) , liver ( 2 , 3 , 4 , 5 , 8 , 9 ) , liver [leptin (mouse), homozygous knockout] ( 3 ) , lung ( 4 ) , mpkCCD (renal) ( 6 ) , pancreas ( 4 )

Upstream Regulation
Treatments:
DDC ( 11 ) , griseofulvin ( 5 , 9 ) , refeeding ( 2 )

Downstream Regulation
Effects of modification on K18:
intracellular localization ( 11 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 11 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

3

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

5

Fortier AM, Riopel K, Désaulniers M, Cadrin M (2010) Novel insights into changes in biochemical properties of keratins 8 and 18 in griseofulvin-induced toxic liver injury. Exp Mol Pathol 89, 117-25
20643122   Curated Info

6

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

7

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

8

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

9

Fausther M, Villeneuve L, Cadrin M (2004) Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice. Comp Hepatol 3, 5
15307891   Curated Info

10

Wang Q, et al. (2004) Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol 78, 821-33
14694114   Curated Info

11

Stumptner C, et al. (2000) Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am J Pathol 156, 77-90
10623656   Curated Info

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