Thr405
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Home > O-GlcNAc Site Page: > Thr405  -  PKM (human)

Site Information
LRRLAPItsDPtEAt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 394791402

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , lymphocyte-blood ( 1 ) , MCF-10A (breast cell) ( 1 ) , MCF-7 (breast cell) ( 1 )

Upstream Regulation
Treatments:
EGF ( 1 ) , PUGNAc ( 1 )

Downstream Regulation
Effects of modification on PKM:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Induce interaction with:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )

References 

1

Wang Y, et al. (2017) O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect. Proc Natl Acad Sci U S A 114, 13732-13737
29229835   Curated Info

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