Ser508
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Home > Phosphorylation Site Page: > Ser508  -  CEACAM1 (human)

Site Information
QQPTQPTsAsPsLTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448536

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 , 5 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 3 , 4 , 5 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 3 ) , T cell leukemia ( 3 ) , liver cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
GSK3B (human) ( 2 )
Treatments:
calphostin_C ( 5 ) , phorbol_ester ( 5 ) , staurosporine ( 5 ) , vanadate ( 4 )

Downstream Regulation
Effects of modification on CEACAM1:
activity, induced ( 5 ) , enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, induced ( 3 ) , cell growth, altered ( 4 ) , transcription, altered ( 1 )
Inhibit interaction with:
CD36 (human) ( 1 )

References 

1

Chean J, et al. (2021) Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. J Biol Chem 297, 101311
34666041   Curated Info

2

Hu W, et al. (2021) Phosphorylation of human CEACAM1-LF by PKA and GSK3β promotes its interaction with β-catenin. J Biol Chem 297, 101305
34656562   Curated Info

3

Li Y, Shively JE (2013) CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with β-catenin. Exp Cell Res 319, 1061-72
23499736   Curated Info

4

Estrera VT, et al. (2001) Signal transduction by the CEACAM1 tumor suppressor. Phosphorylation of serine 503 is required for growth-inhibitory activity. J Biol Chem 276, 15547-53
11278391   Curated Info

5

Fournès B, et al. (2001) The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity. Oncogene 20, 219-30
11313949   Curated Info