Ser159
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Home > Phosphorylation Site Page: > Ser159  -  CDK5 (mouse)

Site Information
GIPVRCYsAEVVTLW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448021

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 1 ) , Lafora disease ( 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 ) , 'brain, hippocampus' ( 1 ) , brain [laforin (mouse), homozygous knockout] ( 2 ) , COS (fibroblast) ( 2 ) , muscle [laforin (mouse), homozygous knockout] ( 2 ) , SKNSH (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
APP (mouse) ( 1 ) , laforin (mouse) ( 2 ) , PSEN1 (mouse) ( 1 )
Treatments:
DI-PHPB ( 1 )

References 

1

Peng Y, et al. (2014) Potassium 2-(1-Hydroxypentyl)-Benzoate Improves Memory Deficits and Attenuates Amyloid and τ Pathologies in a Mouse Model of Alzheimer's Disease. J Pharmacol Exp Ther 350, 361-74
24893984   Curated Info

2

Puri R, Suzuki T, Yamakawa K, Ganesh S (2009) Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. J Biol Chem 284, 22657-63
19542233   Curated Info