Ser212
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Home > Phosphorylation Site Page: > Ser212  -  ACC2 (mouse)

Site Information
PtMRPsMsGLHLVKR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448808

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 5 , 7 ) , phospho-antibody ( 2 , 4 , 6 , 8 , 9 , 10 , 11 ) , western blotting ( 2 , 4 , 6 , 8 , 9 , 10 , 11 )
Disease tissue studied:
melanoma skin cancer ( 7 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 3 ) , 'muscle, skeletal' ( 2 , 8 , 10 ) , 'muscle, skeletal' [CAMKK1 (mouse)] ( 9 ) , heart ( 10 ) , liver ( 1 , 5 , 11 ) , muscle ( 6 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 7 )

Upstream Regulation
Regulatory protein:
IL6 (mouse) ( 2 ) , LKB1 (mouse) ( 10 ) , SCD (mouse) ( 11 )
Treatments:
anoxia ( 10 ) , caffeine ( 8 ) , dantrolene ( 8 ) , exercise ( 2 , 4 ) , ischemia ( 10 ) , KN-93 ( 8 ) , muscle contraction ( 9 ) , STO-609 ( 8 , 9 ) , SU6656 ( 6 )

References 

1

Robles MS, Humphrey SJ, Mann M (2017) Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab 25, 118-127
27818261   Curated Info

2

Gudiksen A, et al. (2016) Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise. PLoS One 11, e0156460
27327080   Curated Info

3

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

4

Knudsen JG, et al. (2015) Exercise-induced regulation of key factors in substrate choice and gluconeogenesis in mouse liver. Mol Cell Biochem 403, 209-17
25702176   Curated Info

5

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

6

Yamada E, et al. (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab 11, 113-24
20142099   Curated Info

7

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

8

Jensen TE, et al. (2007) Caffeine-induced Ca(2+) release increases AMPK-dependent glucose uptake in rodent soleus muscle. Am J Physiol Endocrinol Metab 293, E286-92
17405829   Curated Info

9

Witczak CA, Fujii N, Hirshman MF, Goodyear LJ (2007) Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation. Diabetes 56, 1403-9
17287469   Curated Info

10

Sakamoto K, et al. (2006) Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab 290, E780-8
16332922   Curated Info

11

Dobrzyn P, et al. (2004) Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A 101, 6409-14
15096593   Curated Info