Ser13
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Home > Phosphorylation Site Page: > Ser13  -  K20 (human)

Site Information
RSFHRsLsSSLQAPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 463823

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 3 , 4 , 5 ) , western blotting ( 3 , 5 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , colorectal cancer ( 3 , 5 ) , colorectal carcinoma ( 3 , 5 ) , pancreatic ductal adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 2 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 4 ) , BHK (fibroblast) ( 4 ) , breast ( 1 ) , Caco-2 (intestinal) ( 5 ) , colon ( 5 ) , HT-29 (intestinal) ( 3 , 4 , 5 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 4 )
Kinases, in vitro:
MAPKAPK2 (human) ( 3 )
Treatments:
anisomycin ( 3 , 4 ) , BIRB-0796 ( 3 ) , hypotonic_buffer ( 5 ) , okadaic_acid ( 4 , 5 ) , PHA-781089 ( 3 ) , phorbol_ester ( 4 ) , SB202190 ( 3 ) , SB203580 ( 3 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 4 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

3

Menon MB, et al. (2010) p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. J Biol Chem 285, 33242-51
20724476   Curated Info

4

Zhou Q, et al. (2006) Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker. J Biol Chem 281, 16453-61
16608857   Curated Info

5

Tao GZ, et al. (2006) Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner. J Cell Sci 119, 1425-32
16554440   Curated Info