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Acetylation Site Page:
Lys9 - H3 (rat)

Site Information
RtkQTARkstGGkAP   SwissProt Entrez-Gene
Predicted information:  Scansite
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 463820

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (8), mass spectrometry (3), phospho-antibody (8, 9)
Disease tissue studied: liver cancer (8), hepatocellular carcinoma (8)
Relevant cell line - cell type - tissue: HL1C (hepatocyte) (8), lung (3), RAEC (endothelial) (9)

Controlled by
Treatments: glucose (8), oxysterol (9)



Bagul PK, Deepthi N, Sultana R, Banerjee SK (2015) Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3. J Nutr Biochem 26, 1298-307
26298192   Curated Info


Blaze J, Asok A, Roth TL (2015) Long-term effects of early-life caregiving experiences on brain-derived neurotrophic factor histone acetylation in the adult rat mPFC. Stress 18, 607-15
26305287   Curated Info


Lundby A, et al. (2012) Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep 2, 419-31
22902405   Curated Info


James TT, Aroor AR, Lim RW, Shukla SD (2012) Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol. J Pharmacol Exp Ther 340, 237-47
22025646   Curated Info


Aroor AR, James TT, Jackson DE, Shukla SD (2010) Differential changes in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol. Alcohol Clin Exp Res 34, 1543-51
20586759   Curated Info


Kawakami K, et al. (2009) Age-related difference of site-specific histone modifications in rat liver. Biogerontology 10, 415-21
18814051   Curated Info


Tian F, et al. (2009) Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. J Neurochem 109, 1375-88
19476549   Curated Info


Eckert DT, et al. (2008) Detailed molecular analysis of the induction of the L-PK gene by glucose. Biochem Biophys Res Commun 372, 131-6
18468514   Curated Info


Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info


Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info


Sahar S, et al. (2007) Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 27, 1528-34
17495236   Curated Info


Park PH, Lim RW, Shukla SD (2005) Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression. Am J Physiol Gastrointest Liver Physiol 289, G1124-36
16081763   Curated Info

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