Lys165
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Home > Di-methylation Site Page: > Lys165  -  EEF1A1 (mouse)

Site Information
TEPPYsQkrYEEIVk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3898709

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , breast cancer ( 1 ) , leukemia ( 1 ) , chronic myelogenous leukemia ( 1 ) , T cell leukemia ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
brain ( 1 ) , Flp-In T-Rex-293 (epithelial) ( 1 ) , HAP1 ( 1 ) , HeLa (cervical) ( 1 ) , intestine ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , kidney ( 1 ) , liver ( 1 ) , MCF-7 (breast cell) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , PC3 (prostate cell) ( 1 ) , U87MG (glial) ( 1 ) , uterus ( 1 )

Upstream Regulation
Treatments:
brefeldin_A ( 1 ) , olomoucine ( 1 ) , rapamycin ( 1 ) , serum_starvation ( 1 ) , tanespimycin ( 1 ) , tunicamycin ( 1 )

Downstream Regulation
Effects of modification on EEF1A1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
translation, altered ( 1 )
Inhibit interaction with:
EEF1D (mouse) ( 1 ) , EEF1G (mouse) ( 1 ) , eEF1B (mouse) ( 1 )

References 

1

Malecki J, et al. (2017) The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Res 45, 4370-4389
28108655   Curated Info