Thr153

Site Information
EALLGQAtPPGTGQF SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 463815

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , western blotting ( 2 )
Disease tissue studied:	glioblastoma multiforme ( 1 ) , glioma ( 1 ) , multiple myeloma ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 3 ) , B16 (melanocyte) ( 4 ) , BLM1492 ( 2 ) , COS (fibroblast) ( 4 ) , T98G (glial) ( 1 )

Downstream Regulation
Effects of modification on USF1:	acetylation ( 2 ) , activity, induced ( 1 )
Effects of modification on biological processes:	transcription, induced ( 1 , 2 , 4 ) , transcription, inhibited ( 3 )

References
1	Terragni J, et al. (2011) The E-box Binding Factors Max/Mnt, MITF, and USF1 Act Coordinately with FoxO to Regulate Expression of Proapoptotic and Cell Cycle Control Genes by Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3 Signaling. J Biol Chem 286, 36215-27 21873430 Curated Info
2	Corre S, et al. (2009) Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. J Biol Chem 284, 18851-62 19389701 Curated Info
3	Qi L, et al. (2006) PAI-1 transcriptional regulation during the G0 --> G1 transition in human epidermal keratinocytes. J Cell Biochem 99, 495-507 16622840 Curated Info
4	Galibert MD, Carreira S, Goding CR (2001) The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression. EMBO J 20, 5022-31 11532965 Curated Info