Tyr784
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Home > Phosphorylation Site Page: > Tyr784  -  ITGB3 (mouse)

Site Information
StFTNITyRGT____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448013

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 5 ) , mutation of modification site ( 4 , 6 , 7 ) , phospho-antibody ( 6 ) , western blotting ( 6 )
Disease tissue studied:
leukemia ( 2 , 3 ) , chronic myelogenous leukemia ( 2 , 3 )
Relevant cell line - cell type - tissue:
BaF3 ('B lymphocyte, precursor') ( 2 , 3 , 5 ) , platelet-blood ( 4 , 6 , 7 )

Upstream Regulation
Treatments:
anti-CD40 ( 6 ) , fibrinogen ( 6 ) , integrilin ( 6 )

Downstream Regulation
Effects of modification on ITGB3:
activity, inhibited ( 4 ) , molecular association, regulation ( 7 ) , protein processing ( 4 )
Effects of modification on biological processes:
cell adhesion, altered ( 6 )
Induce interaction with:
SHC1 (mouse) ( 7 )

References 

1

Stiffel V, et al. (2014) EphA4 receptor is a novel negative regulator of osteoclast activity. J Bone Miner Res 29, 804-19
23983218   Curated Info

2

Gu T (2007) CST Curation Set: 3408; Year: 2007; Biosample/Treatment: cell line, Baf3(PLXSN-NEO-FLT3 (D835Y))/IL3 withdrawal; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Gu T (2007) CST Curation Set: 3409; Year: 2007; Biosample/Treatment: cell line, Baf3(PLXSN-NEO-FLT3 (D835Y))/IL3 withdrawal; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Xi X, et al. (2006) Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain. J Biol Chem 281, 29426-30
16935858   Curated Info

5

Gu T (2005) CST Curation Set: 1056; Year: 2005; Biosample/Treatment: cell line, BaF3/-; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Prasad KS, et al. (2003) Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling. Proc Natl Acad Sci U S A 100, 12367-71
14519852   Curated Info

7

Cowan KJ, Law DA, Phillips DR (2000) Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling. J Biol Chem 275, 36423-9
10964917   Curated Info