Thr373
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Home > Phosphorylation Site Page: > Thr373  -  PARP1 (human)

Site Information
AAtPPPstAsAPAAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 463805

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) [IGF1R (mouse)] ( 2 )

Upstream Regulation
Putative in vivo kinases:
ERK2 (human) ( 2 )
Treatments:
PD98059 ( 2 )

Downstream Regulation
Effects of modification on PARP1:
enzymatic activity, induced ( 2 )

References 

1

Kauppinen TM, Gan L, Swanson RA (2013) Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochim Biophys Acta 1833, 1985-91
23597856   Curated Info

2

Kauppinen TM, et al. (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A 103, 7136-41
16627622   Curated Info