Tyr757
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Home > Phosphorylation Site Page: > Tyr757  -  gp130 (mouse)

Site Information
STASTVQySTVVHSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448181

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
chondrocyte ( 1 ) , HEK293T (epithelial) ( 2 ) , splenocyte ( 4 ) , T lymphocyte-spleen ( 3 )

Upstream Regulation
Treatments:
R805 ( 1 )

Downstream Regulation
Effects of modification on gp130:
activity, induced ( 4 ) , molecular association, regulation ( 2 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, altered ( 1 , 2 )
Induce interaction with:
SHP-2 (human) ( 2 ) , SOCS3 (mouse) ( 2 )

References 

1

Shkhyan R, et al. (2023) Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis. Sci Transl Med 15, eabq2395
36947594   Curated Info

2

Fairlie WD, De Souza D, Nicola NA, Baca M (2003) Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2. Biochem J 372, 495-502
12593670   Curated Info

3

Atsumi T, et al. (2002) A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med 196, 979-90
12370259   Curated Info

4

Kamimura D, et al. (2002) Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility. Genes Immun 3, 136-43
12070777   Curated Info