Tyr780
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Home > Phosphorylation Site Page: > Tyr780  -  CBL (mouse)

Site Information
sENEDDGyDVPKPPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448531

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 5 , 6 , 7 , 8 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 3 , 4 , 9 ) , western blotting ( 1 , 3 , 4 , 9 )
Disease tissue studied:
leukemia ( 5 , 6 , 7 , 8 )
Relevant cell line - cell type - tissue:
microvessel endothelial [CBL (mouse), homozygous knockout] ( 3 ) , RAW 264.7 (macrophage) ( 5 , 6 , 7 , 8 ) , SYF (fibroblast) ( 1 ) , thymocyte [CBL (mouse), homozygous knockout] ( 4 )

Upstream Regulation
Regulatory protein:
P38A (mouse) ( 9 )
Putative in vivo kinases:
Src (human) ( 1 )
Treatments:
anisomycin ( 9 ) , antibody ( 4 ) , EGF ( 9 ) , SB202190 ( 9 ) , VEGF ( 3 )

Downstream Regulation
Effects of modification on CBL:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )
Induce interaction with:
Src (human) ( 1 )

References 

1

Matsubara T, et al. (2021) Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation. J Biol Chem, 100790
34019873   Curated Info

2

Buitrago L, Langdon WY, Sanjay A, Kunapuli SP (2011) Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling. Blood 118, 5631-40
21967979   Curated Info

3

Meyer RD, Husain D, Rahimi N (2011) c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCĪ³1. Oncogene 30, 2198-206
21242968   Curated Info

4

Thien CB, et al. (2010) c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 285, 10969-81
20133944   Curated Info

5

Possemato A (2009) CST Curation Set: 7168; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/LPS; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Possemato A (2009) CST Curation Set: 7169; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/MG132; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

7

Possemato A (2009) CST Curation Set: 7167; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/LPS; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Possemato A (2009) CST Curation Set: 7166; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/control; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

9

Frey MR, Dise RS, Edelblum KL, Polk DB (2006) p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J 25, 5683-92
17139251   Curated Info