Ser161

Site Information
RsLsRSMsQEAQRG_ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3893741

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 4 , 5 , 6 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 3 )
Disease tissue studied:	luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 )
Relevant cell line - cell type - tissue:	'muscle, skeletal' ( 4 , 5 ) , breast ( 2 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 6 ) , myocyte-heart ( 3 )

Downstream Regulation
Effects of modification on Telethonin:	protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	cytoskeletal reorganization ( 3 )

References
1	Wirianto M, et al. (2020) The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Cell Rep 32, 108140 32937135 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Candasamy AJ, et al. (2014) Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac Myocytes. J Biol Chem 289, 1282-93 24280220 Curated Info
4	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
5	Højlund K, et al. (2009) In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res 8, 4954-65 19764811 Curated Info
6	Ruse CI, et al. (2008) Motif-specific sampling of phosphoproteomes. J Proteome Res 7, 2140-50 18452278 Curated Info