Lys526

Site Information
QsVyDDTkNHRESNS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3884553

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	brain cancer ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:	'neuron, cortical'-brain ( 1 ) , astrocyte ( 1 ) , brain ( 2 , 3 , 4 ) , C6 (glial) ( 1 )

Downstream Regulation
Effects of modification on GLT1:	protein degradation ( 1 ) , receptor internalization, induced ( 1 )

References
1	Sheldon AL, et al. (2008) Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1. Neurochem Int 53, 296-308 18805448 Curated Info
2	Guo A (2008) CST Curation Set: 3972; Year: 2008; Biosample/Treatment: tissue, brain/Reperfusion; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: Ub(K-e-GG) Curated Info
3	Guo A (2007) CST Curation Set: 3574; Year: 2007; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: Ub(K-e-GG) Curated Info
4	Guo A (2007) CST Curation Set: 3578; Year: 2007; Biosample/Treatment: tissue, brain/ischemia &'\|\|' Reperfusion; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: Ub(K-e-GG) Curated Info