Thr41
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Home > Phosphorylation Site Page: > Thr41  -  CTNNB1 (mouse)

Site Information
GIHsGATtTAPsLSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447583

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 , 16 ) , mutation of modification site ( 3 , 16 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ) , western blotting ( 2 , 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 15 , 16 )
Disease tissue studied:
leukemia ( 5 ) , acute myelogenous leukemia ( 5 ) , neuroblastoma ( 16 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 14 ) , 'neuron, cortical'-brain ( 7 ) , 'neuron, hippocampal'-brain ( 7 ) , 293 (epithelial) ( 15 ) , 293T (epithelial) ( 8 ) , 3T3 (fibroblast) ( 3 ) , brain ( 9 ) , brain [CDK5R1 (mouse)] ( 9 ) , E14tg2a ('stem, embryonic') ( 13 ) , epithelial [PIK3R1 (mouse), homozygous knockout] ( 6 ) , intestine [CK1A (mouse), homozygous knockout] ( 4 ) , L cells (fibroblast) ( 11 , 12 ) , Neuro-2a (neuron) ( 16 ) , stem ( 5 ) , uterus ( 10 )

Upstream Regulation
Regulatory protein:
CDK5R1 (mouse) ( 9 ) , CEACAM1 (mouse) ( 2 ) , CK1A (mouse) ( 4 ) , CTNNB1 (mouse) ( 11 ) , DISC1 (human) ( 7 ) , DISC1 (mouse) ( 7 ) , HRas (mouse) ( 3 ) , Huntingtin (mouse) ( 14 ) , KRas (mouse) ( 3 ) , PIK3R1 (mouse) ( 6 ) , ZBED3 (mouse) ( 8 )
Putative in vivo kinases:
CK1E (human) ( 15 ) , GSK3B (human) ( 8 , 16 )
Kinases, in vitro:
CK1E (human) ( 15 )
Treatments:
differentiation ( 10 ) , LIF ( 13 ) , LLnL ( 16 ) , LY294002 ( 13 ) , MG132 ( 11 ) , NSC-87877 ( 2 ) , QLT0267 ( 12 ) , siRNA ( 7 ) , Wnt3a ( 12 )

Downstream Regulation
Effects of modification on CTNNB1:
protein degradation ( 16 ) , ubiquitination ( 16 )

Disease / Diagnostics Relevance
Relevant diseases:
acute myelogenous leukemia ( 5 )

References 

1

Aloysius A, DasGupta R, Dhawan J (2018) The transcription factor Lef1 switches partners from β-catenin to Smad3 during muscle stem cell quiescence. Sci Signal 11
30042129   Curated Info

2

Wegwitz F, et al. (2016) CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget 7, 63730-63746
27572314   Curated Info

3

Wang MT, et al. (2015) K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell 163, 1237-51
26590425   Curated Info

4

Elyada E, et al. (2011) CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-13
21331045   Curated Info

5

Yeung J, et al. (2010) β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 18, 606-18
21156284   Curated Info

6

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

7

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

8

Chen T, et al. (2009) Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/{beta}-Catenin Signaling. J Biol Chem 284, 6683-9
19141611   Curated Info

9

Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32
18322105   Curated Info

10

Herington JL, Bi J, Martin JD, Bany BM (2007) Beta-catenin (CTNNB1) in the mouse uterus during decidualization and the potential role of two pathways in regulating its degradation. J Histochem Cytochem 55, 963-74
17533218   Curated Info

11

Abe K, Takeichi M (2007) NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron 53, 387-97
17270735   Curated Info

12

Oloumi A, Syam S, Dedhar S (2006) Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25, 7747-57
16799642   Curated Info

13

Paling NR, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-70
15328362   Curated Info

14

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info

15

Sakanaka C (2002) Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. J Biochem (Tokyo) 132, 697-703
12417018   Curated Info

16

Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804
9233789   Curated Info