Ser37
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser37  -  CTNNB1 (mouse)

Site Information
YLDSGIHsGATTTAP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447582

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 , 18 ) , mutation of modification site ( 3 , 9 , 15 , 18 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 16 ) , western blotting ( 2 , 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 18 )
Disease tissue studied:
leukemia ( 5 ) , acute myelogenous leukemia ( 5 ) , neuroblastoma ( 18 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 16 ) , 'neuron, cortical'-brain ( 7 ) , 'neuron, hippocampal'-brain ( 7 ) , 293 (epithelial) ( 9 ) , 293T (epithelial) ( 8 ) , 3T3 (fibroblast) ( 3 ) , brain ( 10 ) , brain [CDK5R1 (mouse)] ( 10 ) , E14tg2a ('stem, embryonic') ( 14 ) , epithelial [PIK3R1 (mouse), homozygous knockout] ( 6 ) , intestine [CK1A (mouse), homozygous knockout] ( 4 ) , L cells (fibroblast) ( 12 , 13 ) , MEF (fibroblast) [JNK1 (mouse), transfection] ( 9 ) , Neuro-2a (neuron) ( 18 ) , stem ( 5 ) , Swiss 3T3 (fibroblast) ( 15 ) , uterus ( 11 )

Upstream Regulation
Regulatory protein:
CDK5R1 (mouse) ( 10 ) , CEACAM1 (mouse) ( 2 ) , CK1A (mouse) ( 4 ) , CTNNB1 (mouse) ( 12 ) , DISC1 (human) ( 7 ) , DISC1 (mouse) ( 7 ) , HRas (mouse) ( 3 ) , Huntingtin (mouse) ( 16 ) , KRas (mouse) ( 3 ) , PIK3R1 (mouse) ( 6 ) , ZBED3 (mouse) ( 8 )
Putative in vivo kinases:
GSK3B (human) ( 8 , 18 )
Kinases, in vitro:
GSK3B (mouse) ( 17 )
Treatments:
differentiation ( 11 ) , LIF ( 14 ) , LLnL ( 18 ) , LY294002 ( 14 ) , MG132 ( 12 ) , NSC-87877 ( 2 ) , QLT0267 ( 13 ) , siRNA ( 7 ) , Wnt3a ( 13 )

Downstream Regulation
Effects of modification on CTNNB1:
protein degradation ( 15 , 18 ) , ubiquitination ( 18 )

Disease / Diagnostics Relevance
Relevant diseases:
acute myelogenous leukemia ( 5 )

References 

1

Aloysius A, DasGupta R, Dhawan J (2018) The transcription factor Lef1 switches partners from β-catenin to Smad3 during muscle stem cell quiescence. Sci Signal 11
30042129   Curated Info

2

Wegwitz F, et al. (2016) CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget 7, 63730-63746
27572314   Curated Info

3

Wang MT, et al. (2015) K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell 163, 1237-51
26590425   Curated Info

4

Elyada E, et al. (2011) CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-13
21331045   Curated Info

5

Yeung J, et al. (2010) β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 18, 606-18
21156284   Curated Info

6

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

7

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

8

Chen T, et al. (2009) Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/{beta}-Catenin Signaling. J Biol Chem 284, 6683-9
19141611   Curated Info

9

Hu D, et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29, 2317-24
18952597   Curated Info

10

Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32
18322105   Curated Info

11

Herington JL, Bi J, Martin JD, Bany BM (2007) Beta-catenin (CTNNB1) in the mouse uterus during decidualization and the potential role of two pathways in regulating its degradation. J Histochem Cytochem 55, 963-74
17533218   Curated Info

12

Abe K, Takeichi M (2007) NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron 53, 387-97
17270735   Curated Info

13

Oloumi A, Syam S, Dedhar S (2006) Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25, 7747-57
16799642   Curated Info

14

Paling NR, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-70
15328362   Curated Info

15

Liu J, Farmer SR (2004) Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem 279, 45020-7
15308623   Curated Info

16

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info

17

Sakanaka C (2002) Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. J Biochem (Tokyo) 132, 697-703
12417018   Curated Info

18

Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804
9233789   Curated Info