Lys121
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Home > Acetylation Site Page: > Lys121  -  C/EBP-epsilon (human)

Site Information
DPRAVAVkEEPRGPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 38557701

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
leukemia ( 2 ) , acute myelogenous leukemia ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , COS (fibroblast) ( 2 ) , HL60 (myeloid) ( 2 ) , NB-4 (myeloid) ( 2 ) , neutrophil ( 2 )

Upstream Regulation
Treatments:
nicotinamide ( 2 ) , valproic acid ( 2 )

Downstream Regulation
Effects of modification on C/EBP-epsilon:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell differentiation, induced ( 2 ) , transcription, induced ( 1 , 2 )
Induce interaction with:
DNA ( 2 )

References 

1

Muraoka M, et al. (2019) C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A. Biochem Biophys Res Commun 516, 293-299
31256937   Curated Info

2

Bartels M, et al. (2015) Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation. Blood 125, 1782-92
25568349   Curated Info

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