Ser177
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Home > Phosphorylation Site Page: > Ser177  -  PDLIM5 (mouse)

Site Information
TPLHLSAsGLHVSAN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 38546304

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , MEF (fibroblast) ( 1 ) , vascular smooth muscle cell ('muscle, smooth') ( 1 )

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (mouse) ( 1 )
Kinases, in vitro:
AMPKA1 (rat) ( 1 )
Treatments:
hypoxia ( 1 )

Downstream Regulation
Effects of modification on PDLIM5:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell motility, inhibited ( 1 ) , cytoskeletal reorganization ( 1 )
Inhibit interaction with:
ARHGEF6 (mouse) ( 1 )

References 

1

Yan Y, et al. (2015) Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5. Nat Commun 6, 6137
25635515   Curated Info