Ser84
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Home > Phosphorylation Site Page: > Ser84  -  Bcl-2 (mouse)

Site Information
ATAGPALsPVPPVVH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448396

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
bone ( 1 ) , muscle ( 2 ) , NCI-H157 (pulmonary) ( 3 ) , NSF/N1.H7 (myeloid) ( 3 ) , preosteoclast ( 1 )

Upstream Regulation
Regulatory protein:
TNFSF11 (human) ( 1 )

Downstream Regulation
Effects of modification on Bcl-2:
molecular association, regulation ( 1 ) , phosphorylation ( 2 ) , protein conformation ( 3 ) , protein stabilization ( 3 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , apoptosis, inhibited ( 3 ) , autophagy, induced ( 2 ) , cell cycle regulation ( 3 )
Inhibit interaction with:
BAX (human) ( 1 )

References 

1

Ke D, et al. (2022) Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis. Mol Med 28, 22
35183115   Curated Info

2

Liu Y, et al. (2020) TLR9 and beclin¿¿1 crosstalk regulates muscle AMPK activation in exercise. Nature
32051584   Curated Info

3

Deng X, Gao F, Flagg T, May WS (2004) Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci U S A 101, 153-8
14660795   Curated Info

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