Ser188
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Home > Phosphorylation Site Page: > Ser188  -  STRAP (mouse)

Site Information
NFNMSVSsMEYIPEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 38410205

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , liver cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HaCaT (keratinocyte) ( 1 ) , hepatocyte-liver ( 1 ) , HepG2 (hepatic) ( 1 ) , MCF-7 (breast cell) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
MELK (mouse) ( 1 )
Kinases, in vitro:
MELK (mouse) ( 1 )
Treatments:
DNCB ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on STRAP:
activity, induced ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , signaling pathway regulation ( 1 )

References 

1

Seong HA, Manoharan R, Ha H (2014) A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways. Cell Cycle 13, 3357-74
25485581   Curated Info