Ser90
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Home > Phosphorylation Site Page: > Ser90  -  ASK1 (mouse)

Site Information
ATRGRGNsGSGGGRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447735

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 ) , 3T3 (fibroblast) ( 2 ) , BAEC (endothelial) ( 3 ) , MEF (fibroblast) ( 1 , 3 )

Upstream Regulation
Regulatory protein:
Akt1 (mouse) ( 3 ) , STRAP (human) ( 2 )
Putative in vivo kinases:
Akt1 (human) ( 3 )
Treatments:
H2O2 ( 2 , 3 )

References 

1

Seong HA, Jung H, Ichijo H, Ha H (2010) Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. J Biol Chem 285, 2397-414
19920149   Curated Info

2

Jung H, Seong HA, Manoharan R, Ha H (2010) Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. J Biol Chem 285, 54-70
19880523   Curated Info

3

Zhang R, et al. (2005) Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene 24, 3954-63
15782121   Curated Info