Ser973
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Home > Phosphorylation Site Page: > Ser973  -  ASK1 (mouse)

Site Information
NEYLRSIsLPVPVLV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447736

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 ) , 3T3 (fibroblast) ( 3 ) , adipocyte-adipose tissue ( 1 ) , HEK293-A (epithelial) ( 1 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Regulatory protein:
STRAP (human) ( 3 )
Putative in vivo kinases:
PKACA (mouse) ( 1 )
Kinases, in vitro:
PDK1 (human) ( 2 )
Treatments:
CL316,243 ( 1 ) , H-89 ( 1 ) , H2O2 ( 3 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 2 )

References 

1

Hattori K, et al. (2020) β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes. PLoS One 15, e0232645
33108364   Curated Info

2

Seong HA, Jung H, Ichijo H, Ha H (2010) Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. J Biol Chem 285, 2397-414
19920149   Curated Info

3

Jung H, Seong HA, Manoharan R, Ha H (2010) Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction. J Biol Chem 285, 54-70
19880523   Curated Info