Ser112
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Home > Phosphorylation Site Page: > Ser112  -  LSD1 (mouse)

Site Information
TPEGRRTsRRKRAKV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3828907

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, hypothalamus, suprachiasmatic nucleus' ( 1 ) , E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , liver ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Kinases, in vitro:
PKCA (human) ( 1 )
Treatments:
dexamethasone ( 1 ) , Go_6976 ( 1 ) , light ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on LSD1:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Nam HJ, et al. (2014) Phosphorylation of LSD1 by PKCĪ± Is Crucial for Circadian Rhythmicity and Phase Resetting. Mol Cell 53, 791-805
24582500   Curated Info