Tyr326
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Home > Phosphorylation Site Page: > Tyr326  -  Akt1 (mouse)

Site Information
EVLEDNDyGRAVDWW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447858

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (mouse) ( 3 )
Kinases, in vitro:
Src (mouse) ( 3 )
Phosphatases, in vitro:
PTPRB (mouse) ( 3 )
Treatments:
EGF ( 3 ) , LY294002 ( 3 ) , PP2 ( 3 )

Downstream Regulation
Effects of modification on Akt1:
enzymatic activity, induced ( 1 , 3 )
Effects of modification on biological processes:
apoptosis, altered ( 3 )

References 

1

Zheng Y, et al. (2010) Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor. Mol Cell Biol 30, 4280-92
20606012   Curated Info

2

Luo W, et al. (2008) Global impact of oncogenic Src on a phosphotyrosine proteome. J Proteome Res 7, 3447-60
18563927   Curated Info

3

Chen R, et al. (2001) Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem 276, 31858-62
11445557   Curated Info