Ser197
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Home > Phosphorylation Site Page: > Ser197  -  FOXO4 (mouse)

Site Information
APRRRAAsMDSSSKL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448516

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 ) , pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' [DNAPK (mouse), homozygous knockout] ( 3 ) , A431 (epithelial) ( 2 ) , A549 (pulmonary) ( 2 ) , adipose tissue [DNAPK (mouse), homozygous knockout] ( 3 ) , DLD1 (intestinal) ( 2 ) , HCT15 (intestinal) ( 2 ) , heart [DNAPK (human), transfection] ( 3 ) , HeLa (cervical) ( 2 ) , liver [DNAPK (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) [DNAPK (mouse), homozygous knockout] ( 3 ) , MIA PaCa-2 (pancreatic) ( 2 ) , NCI-H1299 (pulmonary) ( 2 ) , PaTu (pancreatic) ( 2 )

Upstream Regulation
Regulatory protein:
DNAPK (mouse) ( 3 ) , LIMS1 (human) ( 2 ) , LIMS1 (mouse) ( 2 )
Kinases, in vitro:
Akt1 (human) ( 4 )
Treatments:
ionizing_radiation ( 3 )

Downstream Regulation
Effects of modification on FOXO4:
molecular association, regulation ( 4 )
Effects of modification on biological processes:
transcription, altered ( 4 )
Induce interaction with:
14-3-3 zeta (human) ( 4 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Eke I, et al. (2010) PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest 120, 2516-27
20530873   Curated Info

3

Surucu B, et al. (2008) In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis. J Biol Chem 283, 30025-33
18757368   Curated Info

4

Obsil T, et al. (2003) Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry 42, 15264-72
14690436   Curated Info