Thr344
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Home > Phosphorylation Site Page: > Thr344  -  TRF1 (human)

Site Information
KKERRVGtPQsTKKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3793900

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 3 )

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 3 )

Downstream Regulation
Effects of modification on TRF1:
phosphorylation ( 3 )

References 

1

Sánchez-Vázquez R, Martínez P, Blasco MA (2021) AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet 17, e1009410
33690611   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Wu ZQ, Yang X, Weber G, Liu X (2008) Plk1 phosphorylation of TRF1 is essential for its binding to telomeres. J Biol Chem 283, 25503-13
18625707   Curated Info

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