Tyr207
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Home > Phosphorylation Site Page: > Tyr207  -  BUB3 (human)

Site Information
EGRVAVEyLDPsPEV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 463080

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 , 5 )
Disease tissue studied:
leukemia ( 3 , 4 , 5 ) , acute myelogenous leukemia ( 3 , 4 , 5 ) , lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKM (human) ( 2 )

Downstream Regulation
Effects of modification on BUB3:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , cell growth, induced ( 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
CASC5 (human) ( 2 )

References 

1

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

2

Jiang Y, et al. (2014) PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell 53, 75-87
24316223   Curated Info

3

Gu TL, et al. (2006) Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood 108, 4202-4
16946300   Curated Info

4

Gu T (2006) CST Curation Set: 1398; Year: 2006; Biosample/Treatment: cell line, Marimo/-; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Gu T (2006) CST Curation Set: 1134; Year: 2006; Biosample/Treatment: cell line, KG-1/-; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info