Ser204
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Home > Phosphorylation Site Page: > Ser204  -  PAK1 (mouse)

Site Information
TKsVYTRsVIEPLPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448173

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 10 ) , mass spectrometry ( 5 , 6 , 8 ) , mutation of modification site ( 9 ) , phospho-antibody ( 2 , 7 , 9 , 10 ) , western blotting ( 2 , 7 , 9 , 10 )
Disease tissue studied:
lymphoma ( 9 ) , anaplastic large cell lymphoma ( 9 ) , T cell lymphoma ( 9 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 9 ) , BaF3 ('B lymphocyte, precursor') ( 9 ) , brain ( 6 , 8 ) , dendritic cell ( 2 ) , Karpas-299 (T lymphocyte) ( 9 ) , kidney ( 6 ) , liver ( 7 ) , lymphocyte-blood ( 9 ) , MEF (fibroblast) ( 5 , 7 ) , neutrophil ( 10 )

Upstream Regulation
Regulatory protein:
NPM-ALK (human) ( 9 )
Treatments:
bacterial infection ( 2 ) , fMLP ( 10 ) , LY294002 ( 9 ) , SU6656 ( 9 )

References 

1

Lee J, et al. (2020) IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature
33149299   Curated Info

2

Fabrik I, et al. (2018) The Early Dendritic Cell Signaling Induced by Virulent Francisella tularensis Strain Occurs in Phases and Involves the Activation of Extracellular Signal-Regulated Kinases (ERKs) and p38 In the Later Stage. Mol Cell Proteomics 17, 81-94
29046388   Curated Info

3

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Deguchi A, et al. (2010) LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. J Biol Chem 285, 18283-90
20400510   Curated Info

8

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

9

Colomba A, et al. (2008) Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas. Oncogene 27, 2728-36
17998938   Curated Info

10

Zhan Q, et al. (2003) p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases. J Immunol 171, 3785-93
14500679   Curated Info