Ser199
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Home > Phosphorylation Site Page: > Ser199  -  PAK1 (mouse)

Site Information
PRPEHTKsVYTRsVI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448172

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 5 ) , mutation of modification site ( 4 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Disease tissue studied:
lymphoma ( 4 ) , anaplastic large cell lymphoma ( 4 ) , T cell lymphoma ( 4 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 4 ) , BaF3 ('B lymphocyte, precursor') ( 4 ) , Karpas-299 (T lymphocyte) ( 4 ) , liver ( 3 ) , lymphocyte-blood ( 4 ) , MEF (fibroblast) ( 3 ) , neuron-'brain, cerebral cortex' ( 2 ) , neutrophil ( 5 )

Upstream Regulation
Regulatory protein:
FMR1 (mouse) ( 2 ) , NPM-ALK (human) ( 4 )
Treatments:
fMLP ( 5 ) , LY294002 ( 4 ) , SU6656 ( 4 )

References 

1

Lee J, et al. (2020) IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature
33149299   Curated Info

2

Pyronneau A, et al. (2017) Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome. Sci Signal 10
29114038   Curated Info

3

Deguchi A, et al. (2010) LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. J Biol Chem 285, 18283-90
20400510   Curated Info

4

Colomba A, et al. (2008) Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas. Oncogene 27, 2728-36
17998938   Curated Info

5

Zhan Q, et al. (2003) p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases. J Immunol 171, 3785-93
14500679   Curated Info