Ser362
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Home > Phosphorylation Site Page: > Ser362  -  Fos (mouse)

Site Information
AAAHRKGsSSNEPSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448481

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 3 ) , bone ( 3 ) , BV2 (microglia) ( 1 ) , fibroblast-embryo ( 2 ) , hematopoietic progenitor-bone marrow ( 2 ) , monocyte ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKACA (mouse) ( 1 ) , RSK2 (mouse) ( 3 )
Treatments:
LPS ( 1 ) , M-CSF ( 3 ) , MG132 ( 3 )

Downstream Regulation
Effects of modification on Fos:
activity, induced ( 2 ) , molecular association, regulation ( 1 ) , protein stabilization ( 2 , 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , signaling pathway regulation ( 2 ) , transcription, altered ( 2 )
Induce interaction with:
ER-beta (mouse) ( 1 )

References 

1

Saijo K, et al. (2011) An ADIOL-ERĪ²-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145, 584-95
21565615   Curated Info

2

Bakiri L, et al. (2011) Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene 30, 1506-17
21119595   Curated Info

3

David JP, et al. (2005) Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J Clin Invest 115, 664-72
15719069   Curated Info