Thr325
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Home > Phosphorylation Site Page: > Thr325  -  Fos (human)

Site Information
TELEPLCtPVVTCtP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448483

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
HBXIP (human) ( 1 )
Putative in vivo kinases:
ERK1 (human) ( 1 )
Treatments:
mechanical stress ( 2 ) , PD98059 ( 1 ) , SB203580 ( 2 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , transcription, induced ( 1 )

References 

1

Zhang Y, et al. (2013) The Nuclear Import of Oncoprotein Hepatitis B X-interacting Protein Depends on Interacting with c-Fos and Phosphorylation of Both Proteins in Breast Cancer Cells. J Biol Chem 288, 18961-74
23667255   Curated Info

2

Lewthwaite JC, et al. (2006) A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. J Biol Chem 281, 11011-8
16464862   Curated Info

3

Bossis G, et al. (2005) Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol 25, 6964-79
16055710   Curated Info