Ser374
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Home > Phosphorylation Site Page: > Ser374  -  Fos (human)

Site Information
PSSDSLSsPtLLAL_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448482

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 4 , 5 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
breast cancer ( 3 , 4 ) , cervical cancer ( 5 ) , cervical adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
HBXIP (human) ( 3 )
Putative in vivo kinases:
ERK1 (human) ( 3 )
Treatments:
EGF ( 2 ) , PD98059 ( 3 ) , siRNA ( 3 ) , U0126 ( 2 )

Downstream Regulation
Effects of modification on Fos:
molecular association, regulation ( 2 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 3 ) , cell growth, induced ( 2 ) , transcription, induced ( 3 )
Inhibit interaction with:
FBXL10 (human) ( 2 )

References 

1

De S, Campbell C, Venkitaraman AR, Esposito A (2020) Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage. Cell Rep
32075732   Curated Info

2

Han XR, et al. (2016) KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene 35, 4179-90
26725323   Curated Info

3

Zhang Y, et al. (2013) The Nuclear Import of Oncoprotein Hepatitis B X-interacting Protein Depends on Interacting with c-Fos and Phosphorylation of Both Proteins in Breast Cancer Cells. J Biol Chem 288, 18961-74
23667255   Curated Info

4

Imami K, et al. (2012) Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics 11, 1741-57
22964224   Curated Info

5

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

6

Bossis G, et al. (2005) Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol 25, 6964-79
16055710   Curated Info