Thr356
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Home > Phosphorylation Site Page: > Thr356  -  GSK3B (mouse)

Site Information
KLPNGRDtPALFNFT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 37043704

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
3T3-L1 (fibroblast) ( 1 ) , adipose tissue ( 1 ) , HEK293T (epithelial) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
DYRK1A (mouse) ( 1 )
Kinases, in vitro:
DYRK1A (mouse) ( 1 )
Treatments:
high-fat diet ( 1 ) , normal chow diet ( 1 )

Downstream Regulation
Effects of modification on GSK3B:
enzymatic activity, inhibited ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , transcription, induced ( 1 )

References 

1

Song WJ, et al. (2015) Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). J Biol Chem 290, 2321-33
25477508   Curated Info

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