Ser242
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Home > Phosphorylation Site Page: > Ser242  -  NDEL1 (human)

Site Information
IPNGFGtsPLtPSAR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3685801

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 7 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 6 ) , mutation of modification site ( 1 , 7 )
Disease tissue studied:
breast cancer ( 3 ) , cervical cancer ( 6 ) , cervical adenocarcinoma ( 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 7 )
Treatments:
nocodazole ( 6 , 7 )

Downstream Regulation
Effects of modification on NDEL1:
intracellular localization ( 7 ) , molecular association, regulation ( 1 , 7 )
Induce interaction with:
DYNC1I1 (human) ( 1 ) , PAFAH1B1 (human) ( 7 )

References 

1

Garrott SR, et al. (2023) Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways. J Biol Chem 299, 104735
37086789   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

4

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

5

Moritz A (2010) CST Curation Set: 9057; Year: 2010; Biosample/Treatment: cell line, HeLa/nocodazole; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpTPAntibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK Substrates (PXTP) (46G11) Rabbit mAb Cat#: 4391, PTMScan(R) Phospho-MAPK Substrate Motif (PXpTP) Immunoaffinity Beads Cat#: 1983
Curated Info

6

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

7

Yan X, et al. (2003) Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol 23, 1239-50
12556484   Curated Info