Ser1048

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Home > Phosphorylation Site Page: > Ser1048 - NMDAR2A (rat)

Site Information
NRTHSLKsPRYLPEE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 36747000

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	brain ( 1 ) , COS7 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , neuron ( 1 )

Upstream Regulation
Putative in vivo kinases:	DYRK1A (human) ( 1 )
Kinases, in vitro:	DYRK1A (human) ( 1 )

Downstream Regulation
Effects of modification on NMDAR2A:	activity, induced ( 1 ) , receptor internalization, inhibited ( 1 )

References
1	Grau C, et al. (2014) DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors. Front Cell Neurosci 8, 331 25368549 Curated Info

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