Ser50
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Home > Phosphorylation Site Page: > Ser50  -  SNAPIN (mouse)

Site Information
HVHAVREsQVELREQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448453

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 2 )
Disease tissue studied:
neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , 'neuron, hippocampal'-brain ( 2 ) , Neuro-2a (neuron) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKACA (mouse) ( 3 )

Downstream Regulation
Effects of modification on SNAPIN:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
cell growth, inhibited ( 2 ) , cell motility, inhibited ( 1 )
Induce interaction with:
SNAP-25 (mouse) ( 1 , 2 )
Inhibit interaction with:
DNCLI1 (mouse) ( 1 )

References 

1

Di Giovanni J, Sheng ZH (2015) Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting. EMBO J 34, 2059-77
26108535   Curated Info

2

Wu CS, et al. (2011) Type VI Adenylyl Cyclase Regulates Neurite Extension by Binding to Snapin and Snap25. Mol Cell Biol 31, 4874-86
21986494   Curated Info

3

Chheda MG, et al. (2001) Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat Cell Biol 3, 331-8
11283605   Curated Info

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