Tyr1138
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr1138  -  LEPR (mouse)

Site Information
SGENFVPyMPQFQTC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448434

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 9 ) , mutation of modification site ( 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ) , phospho-antibody ( 2 , 10 ) , western blotting ( 2 , 9 )
Disease tissue studied:
liver cancer ( 4 )
Relevant cell line - cell type - tissue:
'brain, hypothalamus' ( 1 , 7 ) , 293 (epithelial) ( 8 , 9 ) , blood ( 2 ) , gamma 2a (fibroblast) ( 5 ) , HEK293T (epithelial) ( 10 ) , HepG2 (hepatic) ( 4 ) , HIT-T15 (pancreatic) ( 6 ) , liver ( 2 ) , RINm5F ( 4 )

Upstream Regulation
Treatments:
Epo ( 9 ) , high-fat diet ( 2 ) , leptin ( 2 , 10 ) , normal chow diet ( 2 )

Downstream Regulation
Effects of modification on LEPR:
activity, induced ( 6 ) , molecular association, regulation ( 8 , 9 , 10 ) , phosphorylation ( 2 , 5 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 , 2 ) , transcription, altered ( 9 ) , transcription, induced ( 8 )
Induce interaction with:
SHP-2 (mouse) ( 10 ) , STAT3 (human) ( 8 ) , STAT3 (mouse) ( 9 )

References 

1

Zhang Q, et al. (2014) Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure. J Biol Chem 289, 1779-87
24302741   Curated Info

2

Imajo K, et al. (2012) Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling. Cell Metab 16, 44-54
22768838   Curated Info

3

Vong L, et al. (2011) Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron 71, 142-54
21745644   Curated Info

4

Knobelspies H, et al. (2010) Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem 11, 2
20059770   Curated Info

5

Jiang L, Li Z, Rui L (2008) Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways. J Biol Chem 283, 28066-73
18718905   Curated Info

6

Hekerman P, et al. (2005) Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272, 109-19
15634336   Curated Info

7

Bates SH, et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856-9
12594516   Curated Info

8

Bjorbak C, et al. (2000) SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275, 40649-57
11018044   Curated Info

9

Banks AS, Davis SM, Bates SH, Myers MG (2000) Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275, 14563-72
10799542   Curated Info

10

Li C, Friedman JM (1999) Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A 96, 9677-82
10449753   Curated Info