Ser250
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Home > Phosphorylation Site Page: > Ser250  -  PXN (mouse)

Site Information
SsPQRVTsSQQQTRI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3653284

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
liver ( 2 , 3 , 4 ) , MEF-3T3 ( 1 )

Upstream Regulation
Putative in vivo kinases:
SLK (mouse) ( 1 )
Kinases, in vitro:
SLK (human) ( 1 )
Treatments:
scratch wound ( 1 )

Downstream Regulation
Effects of modification on PXN:
intracellular localization ( 1 )
Effects of modification on biological processes:
cell motility, induced ( 1 )

References 

1

Quizi JL, et al. (2013) SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration. Oncogene 32, 4656-63
23128389   Curated Info

2

Possemato A (2010) CST Curation Set: 9747; Year: 2010; Biosample/Treatment: tissue, liver/control; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

3

Possemato A (2010) CST Curation Set: 9748; Year: 2010; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

4

Possemato A (2010) CST Curation Set: 9746; Year: 2010; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info