Tyr241
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Home > Phosphorylation Site Page: > Tyr241  -  PDHK1 (mouse)

Site Information
ARRLCDLyyVNSPEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 462384

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 1 ) , chronic myelogenous leukemia ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on biological processes:
cell growth, induced ( 1 )

References 

1

Hitosugi T, et al. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell 44, 864-77
22195962   Curated Info