Lys120
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Home > Acetylation Site Page: > Lys120  -  14-3-3 zeta (human)

Site Information
EskVFYLkMkGDyyR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3649468
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 10 , 11 , 12 ) , mass spectrometry (in vitro) ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , colorectal cancer ( 10 ) , colorectal carcinoma ( 10 ) , gastric cancer ( 6 ) , lung cancer ( 2 , 3 ) , non-small cell lung cancer ( 4 , 5 , 7 , 8 ) , non-small cell lung adenocarcinoma ( 2 , 5 ) , non-small cell squamous cell lung carcinoma ( 8 ) , small-cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 2 , 11 ) , DMS79 (pulmonary) ( 3 ) , HCT116 (intestinal) ( 10 , 12 ) , HEK293T (epithelial) ( 1 ) , Jurkat (T lymphocyte) ( 11 ) , lung ( 3 ) , MDA-MB-231 (breast cell) ( 1 ) , MKN-45 (gastric) ( 6 ) , MV4-11 (macrophage) ( 11 ) , NCI-H128 (pulmonary) ( 3 ) , NCI-H1417 (pulmonary) ( 3 ) , NCI-H1703 (squamous) ( 8 ) , NCI-H209 (pulmonary) ( 3 ) , NCI-H2228 (pulmonary) ( 5 ) , NCI-H3122 (pulmonary) ( 4 ) , NCI-H3255 (pulmonary) ( 7 ) , NCI-H524 (pulmonary) ( 3 )

Upstream Regulation
Treatments:
tubacin ( 1 ) , vorinostat ( 11 )

Downstream Regulation
Effects of modification on 14-3-3 zeta:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )
Inhibit interaction with:
AS160 (human) ( 1 ) , ATG9A (human) ( 1 ) , BAD (human) ( 1 ) , KIF11 (human) ( 1 )

References 

1

Mortenson JB, et al. (2015) Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. J Biol Chem 290, 12487-96
25770209   Curated Info

2

Wu Q, et al. (2015) Suberoylanilide hydroxamic acid treatment reveals crosstalks among proteome, ubiquitylome and acetylome in non-small cell lung cancer A549 cell line. Sci Rep 5, 9520
25825284   Curated Info

3

Rikova K (2013) CST Curation Set: 20213; Year: 2013; Biosample/Treatment: cell line, H1417, DMS79, H128, H209, H524; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

4

Rikova K (2013) CST Curation Set: 18855; Year: 2013; Biosample/Treatment: cell line, H3122/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

5

Rikova K (2013) CST Curation Set: 18854; Year: 2013; Biosample/Treatment: cell line, H2228/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

6

Rikova K (2012) CST Curation Set: 16030; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

7

Rikova K (2012) CST Curation Set: 16031; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

8

Rikova K (2012) CST Curation Set: 16032; Year: 2012; Biosample/Treatment: cell line, H1703/gleevec; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

9

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

10

Moritz A (2010) CST Curation Set: 9797; Year: 2010; Biosample/Treatment: cell line, HCT 116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

11

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

12

Li Y (2006) CST Curation Set: 2000; Year: 2006; Biosample/Treatment: cell line, HCT116/serum starved &'||' EGF; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

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