Ser64
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Home > Phosphorylation Site Page: > Ser64  -  GUCY1A1 (rat)

Site Information
SHPQRKTsRNRVYLH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3647001

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
A7r5 ('muscle, smooth') ( 1 ) , aorta ( 1 ) , COSm6 (renal) ( 1 ) , lung ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKG1 (human) ( 1 )
Treatments:
8pCPT-cGMP ( 1 ) , bradykinin ( 1 ) , L-NAME ( 1 ) , peptide_agonist ( 1 ) , peptide_antagonist ( 1 ) , Rp-8pCPT-cGMPS ( 1 ) , SNP ( 1 )

Downstream Regulation
Effects of modification on GUCY1A1:
enzymatic activity, inhibited ( 1 ) , phosphorylation ( 1 )

References 

1

Zhou Z, et al. (2008) Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity. Arterioscler Thromb Vasc Biol 28, 1803-10
18635821   Curated Info