Ser792
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Home > Phosphorylation Site Page: > Ser792  -  AR (human)

Site Information
CVRMRHLsQEFGWLQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448415

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 2 , 3 )
Disease tissue studied:
prostate cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PIK3C2A (human) ( 2 )
Putative in vivo kinases:
Akt1 (human) ( 2 , 3 , 4 )
Kinases, in vitro:
Akt1 (human) ( 4 , 5 )
Treatments:
IGF-1 ( 3 , 4 ) , LY294002 ( 2 , 3 , 4 )

Downstream Regulation
Effects of modification on AR:
intracellular localization ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , chromatin organization, altered ( 1 ) , transcription, altered ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 1 )

References 

1

McCall P, et al. (2013) Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients. Int J Mol Sci 14, 16656-71
23945560   Curated Info

2

Palazzolo I, et al. (2007) Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity. Hum Mol Genet 16, 1593-603
17470458   Curated Info

3

Lin HK, et al. (2003) Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J Biol Chem 278, 50902-7
14555644   Curated Info

4

Lin HK, Yeh S, Kang HY, Chang C (2001) Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A 98, 7200-5
11404460   Curated Info

5

Wen Y, et al. (2000) HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res 60, 6841-5
11156376   Curated Info