Leu309
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Home > Methylation Site Page: > Leu309  -  PPP2CA (rat)

Site Information
RRTPDyFl_______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3627520

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , modification-specific antibody ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 , 2 )

Upstream Regulation
Treatments:
folic acid ( 2 ) , homocysteine ( 1 , 2 ) , vitamin_B12 ( 2 )

Downstream Regulation
Effects of modification on PPP2CA:
molecular association, regulation ( 2 )
Inhibit interaction with:
PPP2CB (rat) ( 2 )

References 

1

Chai GS, et al. (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124, 388-96
23157378   Curated Info

2

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info