Leu309
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Home > Methylation Site Page: > Leu309  -  PPP2CA (human)

Site Information
RRtPDyFl_______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3627520

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 4 ) , electrophoretic mobility shift ( 4 ) , modification-specific antibody ( 1 ) , peptide sequencing ( 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 4 )
Disease tissue studied:
breast cancer ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
acetone ( 4 ) , ethanol ( 4 ) , freeze/thaw ( 4 ) , microcystin-LR ( 1 ) , PAN ( 4 )

Downstream Regulation
Effects of modification on PPP2CA:
enzymatic activity, induced ( 4 )

References 

1

Sun Y, et al. (2014) Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line. Environ Toxicol 29, 1236-44
23436320   Curated Info

2

Li J, et al. (2014) Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target. Cancer Biol Ther 15, 128-34
24253382   Curated Info

3

Luo Y, et al. (2013) PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta 1833, 1235-43
23428800   Curated Info

4

Favre B, Zolnierowicz S, Turowski P, Hemmings BA (1994) The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. J Biol Chem 269, 16311-7
8206937   Curated Info