Ser64
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Home > Phosphorylation Site Page: > Ser64  -  BID (mouse)

Site Information
QtDGsQAsRsFNQGR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448405

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 3 ) , MEF (fibroblast) [IGF1R (mouse)] ( 2 )

Upstream Regulation
Treatments:
aphidicolin ( 2 ) , etoposide ( 1 , 2 ) , granzyme_B ( 1 ) , hydroxyurea ( 2 ) , LY294002 ( 2 ) , mitomycin_C ( 2 ) , perforin ( 1 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on BID:
protein stabilization ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 )

References 

1

Brasacchio D, et al. (2014) A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage. Cell Death Differ 21, 748-60
24464226   Curated Info

2

Zinkel SS, et al. (2005) A role for proapoptotic BID in the DNA-damage response. Cell 122, 579-91
16122425   Curated Info

3

Desagher S, et al. (2001) Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell 8, 601-11
11583622   Curated Info

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